Letlapa la Nicolsamide
Niclosamide ke salicylanilide e nang le bioavailable ka molomo e nang le chlorinated salicylanilide, e nang le ts'ebetso ea anthelmintic le e ka bang teng e thibelang likokoana-hloko.Holim'a taolo ea molomo, niclosamide ka ho khetheha e baka ho senyeha ha mofuta oa androgen receptor (AR) V7 (AR-V7) ka tsela ea proteasome-mediated.Sena se theola polelo ea mofuta oa AR, se thibela ts'ebetso ea mongolo oa AR-V7-mediated, 'me se fokotsa ho hira AR-V7 ho motšehetsi oa liphatsa tsa lefutso tsa prostate-specific antigen (PSA).Niclosamide hape e thibela phosphorylation ea AR-V7-mediated STAT3 le ho kenya tshebetsong.Sena se thibela pontšo ea AR/STAT3-mediated mme se thibela polelo ea STAT3 liphatsa tsa lefutso.Ka kakaretso, sena se ka thibela kholo ea lisele tsa mofetše tsa AR-V7-overexpressing.Phapang ea AR-V7, e kenyellelitsoeng ke splicing e ts'oanang ea AR exons 1/2/3/CE3, e laoloa ka mefuta e fapaneng ea lisele tsa mofetše, 'me e amahanngoa le tsoelo-pele ea mofetše le ho hanyetsa litlhare tse lebisitsoeng ho AR.
Moetso:
Bolus cotnains 1250 mg niclosamide
Sesupo:
Bakeng sa likokoana-hloko tse tšoaelitsoeng ke paramphistomes, cestodiasis, tse kang likhomo le linku tsa moniezia, avitellina centripunctata, joalo-joalo.
Tekanyo le Tšebeliso:
Ka molomo, boima bo bong le bo bong ba 1kg.
Likhomo: 40-60mg
Linku: 60-70mg
Nako ea ho hula:
Linku: matsatsi a 28.
Likhomo: matsatsi a 28.
Boholo ba sephutheloana: Letlapa la 5 ka blister, blister tse 10 ka lebokoseng
